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India builds synthetic intelligence system to choose carcinogens from chemical crowd : The Tribune India

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India builds synthetic intelligence system to choose carcinogens from chemical crowd : The Tribune India

Tribune Information Service

Aditi Tandon

New Delhi, August 30

A group of Indian scientists is making world waves to develop an AI-based system that may choose cancer-causing compounds from a chemical crowd, providing enormous potential to alter the face of the most cancers discovery panorama.

The paper, “Artificial Intelligence Reveals Human Cancer-Causing Metabolites,” revealed within the internationally acclaimed “Nature Chemical Biology,” presents a brand new AI strategy that may determine carcinogens from amongst a sea of ​​molecules.

The work of 4 collaborating institutes – Indraprastha Institute of Info Expertise Delhi, IIT-Ropar, CSIR Institute of Genomics and Integrative Biology and Rajiv Gandhi Most cancers Institute – has already been hailed as a game-changer within the discipline of oncology contemplating solely 5-10 per cent of cancers are hereditary. The remaining is because of publicity to carcinogens.

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“Since more than 90 percent of cancers are caused by exposure to compounds, the ability of our AI method to accurately identify a carcinogen can make a huge difference in response to cancer. Over the past few decades, more than 700 drugs are approved by the Food and Drug Administration because they were later found to be carcinogenic even though they passed the trial stages.It is a huge burden for drugs to determine the potential for carcinogenicity of a compound.Dr. Gaurav Ahuja, senior author of the study, told Today’s Tribune that the AI ​​system Our, Metabokiller, is a reliable way to accurately detect carcinogenic compounds.Indian researchers have demonstrated the value of their AI model by identifying two compounds (none of the cancer detection models currently in use indicate they cause cancer) as causing cancer and demonstrating it in experiments.

Ahuja and collaborator Dr. Debarka Sengupta say current predictive models for predicting cancer primarily examine compounds to see if they cause DNA damage and predict cancer based on this knowledge. But a potential cancer-causing compound may not primarily damage DNA alone. Carcinogens could have many other biochemical properties that our AI model evaluates for detection,” says Ahuja.

What does “Metabokiller” do?

Metabokiller follows biochemical properties recognized to be related to carcinogens to detect most cancers compounds – a possible carcinogen might result in cell proliferation (cell division), genetic instability, anti-apoptosis (the flexibility of the cell to not die), and epigenetic response (adjustments in DNA ) and will have an electrophilic character (it induces a optimistic cost to have an effect on the negatively charged DNA).

4 institutes are making world waves

  • Indraprastha Institute of Info Expertise Delhi, IIT-Ropar, CSIR-Institute of Genomics, Integrative Biology and Rajiv Gandhi Most cancers Institute are collaborating institutes
  • The research, revealed within the world-renowned journal Nature Chemical Biology, provides a brand new AI strategy to determine carcinogens from amongst a sea of ​​molecules.

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